Van de Ven Double Ends Everton's Run at Brand New Home Ground
Micky van de Ven emerged as the first backline player to score twice in a Premier League game for Tottenham since Jan Vertonghen in spring 2013.
Match summary
Micky Van de Ven heads home twice in opening period
Everton's defender has equalizer ruled after video check
Pape Matar Sarr nets final goal in dying moments
This loss is Everton's first at their new ground
The Tottenham defender found the net twice as Tottenham prolonged their unbeaten run in away games in the top division and handed the Toffees their first defeat at their new home.
Everton were undefeated in their five previous fixtures at their new ground at the dockside location, having left their historic home behind after more than a century at the end of the previous campaign.
But Tottenham's leader Van de Ven pounced on two occasions from set-pieces in the opening 45 minutes to place their strong form at risk, and they were unable to mount a comeback before Pape Matar Sarr - set up by former Toffees attacker Richarlison - nodded in a final goal to put the game to bed.
Jake O'Brien believed he had equalized the scores five minutes after Van de Ven's opener, glancing a powerful header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, failed to convert a number of chances, while the Italian goalkeeper made a series of excellent saves to ensure Tottenham went five matches on the road without defeat in the English top flight.
But the video assistant referee intervened, advising the match official to review the goal on the pitchside monitor and the referee ruled that the winger and the attacker were in offside positions and had impeded with the Spurs keeper.
This victory moves the manager's side into third place in the division, a handful of points off local foes and table-toppers the Gunners.
The Merseyside club remain 14th and are six points clear of the relegation zone.
Tottenham analysis: The defender excels in role at both ends of pitch
Following a uninspiring midweek display in the Champions League against Monaco, where they managed a only two shots on target, Frank opted for the French striker up front instead of ex-Everton forward the Brazilian.
The summer signing was failed to make much of an impact before being substituted for Richarlison after an hour on the field, but it turns out he proved unnecessary in the final outcome.
Centre-back Van de Ven converted into an offensive threat to be reckoned with.
Spurs' opening strike came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball back across the face of goal for an unmarked Van de Ven to score.
And Ven de Ven - stepping up as captain in the Argentine's unavailability - added his second in first-half stoppage time as he rose above the England keeper to nod in.
The Dutchman was just as impressive in defence, combining effectively with Kevin Danso as the duo dealt excellently with the numerous deliveries thrown their way by the opposition.
Everton analysis: Toffees lacking striker's instinct
Everton's recent stadium had been a fortress, but it seems the freshness may have faded slightly and fans flocked to the exits after the midfielder's third for Tottenham.
The break in the team's winning streak at home will not be a massive concern for the manager, but their striker situation will be.
Beto and the other striker - the Everton's pair of recognised strikers - had netted only a single goal between them before the weekend's outing.
And they were unable to add to that miserable record on a damp and dreary evening on in Liverpool.
Beto's form was epitomized when he chose to bicycle-kick a clear chance from near the goal, even with having space and time to reposition for a simpler attempt that would have challenged the keeper.
Barry, too, was unable to make an impact after replacing the starter in the second half.
It was not for a shortage of opportunity. Most of Everton's offensive moves came through Grealish and Ndiaye, who relentlessly delivered dangerous crosses into the Spurs penalty area.
What next for both teams?
The Toffees: The team head to the Stadium of Light in the top flight on early November at 20:00 GMT.
Tottenham: The London club go to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup match against the Magpies.